Sherene Shalhub, MD MPH FACS-New Studies

Hi Brian,

Hope this finds you well, I am working on the grant application for PCORI as I mentioned to you earlier. So more information will be coming in the next week.

“Also, I recently published these manuscripts recently that you may find to be of interest to your readership’

Association of variant arch anatomy with type B aortic dissection and hemodynamic mechanisms

https://www.jvascsurg.org/article/S0741-5214(18)30888-7/fulltext

· Type of Research: Retrospective cohort study

· Take Home Message: Compared with 367 controls, variant arch anatomy was observed on computed tomography scans of 40.5% of 185 patients with type B aortic dissection. On four-dimensional flow magnetic resonance imaging, patients with bovine arch had higher systolic wall shear stress compared with those with normal arch anatomy.

· Recommendation: This study suggests that aortic arch anatomy variants are more common in patients with type B aortic dissections, which might be explained by higher wall sheer shear stress.

Endovascular thoracic aortic repair in confirmed or suspected genetically triggered thoracic aortic dissection

https://www.jvascsurg.org/article/S0741-5214(18)30132-0/fulltext

· Type of Research: Retrospective analysis of prospectively collected National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) data

· Take Home Message: In 31 patients with descending thoracic aorta dissection treated with thoracic endovascular aortic repair, 13 (42%) required reintervention at a median of 7 months, 3 for retrograde ascending aorta dissection and 7 for thoracoabdominal aortic aneurysm repairs with stent graft explantation.

· Recommendation: This study suggests that patients with genetically triggered descending thoracic aorta dissection, treated with thoracic endovascular aortic repair, have a high risk of retrograde aortic dissection and reintervention.

Testing patterns for genetically triggered aortic and arterial aneurysms and dissections at an academic center

https://www.jvascsurg.org/article/S0741-5214(18)30052-1/fulltext

· Type of Research: Retrospective cohort study

· Take Home Message: In 36% of 75 patients suspected of having heritable mutations related to aortic or arterial aneurysms or dissections, genetic testing results were positive. Pathogenic mutation was confirmed in 57% of patients with a family history of diagnosed mutation and in 42% of those with a personal history of ascending aortic disease.

· Recommendation: The authors suggest appropriate genetic consultation and selective testing in patients suspected of having genetically triggered vascular disease and suggest the need for novel gene discovery.

Warm regards,

Sherene Shalhub, MD MPH FACS

Associate Professor of Surgery

Division of Vascular Surgery

University of Washington

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